Ingredients
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Glycerin is a naturally derived humectant—a ingredient that draws moisture from the air into your skin. It's one of the most widely used and well-studied moisturizing agents in skincare, helping skin feel softer and more hydrated.
Benefits
- Attracts and retains moisture in the skin
- Improves skin hydration and softness
- Helps strengthen skin barrier function
- Suitable for most skin types, including sensitive skin
Science: The Cosmetic Ingredient Review Expert Panel concluded glycerin is safe as used in cosmetics across all concentrations. Research shows glycerin effectively improves skin hydration and is well-tolerated with minimal irritation risk. It is also referenced in clinical guidelines for managing inflammatory skin conditions and maintaining skin integrity.
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Sucrose is a natural sugar derived from sugar cane or sugar beets. In skincare, it's primarily used as a humectant to help the skin retain moisture, and as a texture enhancer in formulations. It can also serve as a gentle exfoliant in some products when used in granulated form.
Benefits
- Helps skin retain moisture
- Provides humectant properties to improve hydration
- Generally well-tolerated by most skin types
Potential concerns
- May feed acne-causing bacteria if not properly formulated
- Can leave skin sticky if used in high concentrations
- Potential for irritation in individuals with sensitive skin if concentration is excessive
Science: Limited peer-reviewed data available specifically evaluating sucrose as a skincare active ingredient. The provided research discusses sucrose only as a laboratory tool for isolating nanoparticles, not for its direct skincare benefits. Sucrose's use in cosmetics is well-established as a safe humectant and preservative agent based on decades of cosmetic industry use.
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Green tea leaf extract is derived from the leaves of the Camellia sinensis plant and contains powerful antioxidants called polyphenols. In skincare, it helps protect skin from environmental damage and may reduce inflammation and excess oil production.
Benefits
- Antioxidant protection against environmental stressors
- May help reduce redness and calm irritated skin
- Can help mattify oily or combination skin
Potential concerns
- May cause mild irritation or dryness in sensitive skin types
- Can increase sun sensitivity in some individuals
Science: Green tea polyphenols, particularly EGCG, have been extensively studied in skincare research and demonstrated antioxidant and anti-inflammatory properties. Well-established safety profile with low sensitization risk in cosmetic concentrations.
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Sodium hyaluronate is the salt form of hyaluronic acid, a naturally occurring substance found in your skin that acts like a moisture magnet. In skincare products, it absorbs water from the environment and binds it to your skin, helping to hydrate and plump the skin's surface.
Benefits
- Delivers intense hydration to the skin
- Helps reduce the appearance of fine lines by improving skin moisture
- Supports skin barrier function
- Suitable for all skin types, including sensitive and oily skin
Potential concerns
- In very dry climates with low humidity, it may draw moisture from deeper skin layers if not sealed with an occlusive product
- Rare allergic reactions are possible but extremely uncommon
Science: While the provided research focuses on intra-articular injections for joint health (showing good safety and efficacy), hyaluronic acid and its salt form are well-established in dermatology for topical hydration. The molecule's safety profile is well-documented across decades of use in medical and cosmetic applications, with severe adverse reactions being extremely rare.
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Lactobacillus Ferment Lysate is a fermentation byproduct made by breaking down beneficial bacteria (lactobacillus). It's used in skincare for its potential to support skin's natural microbiome and barrier function, similar to how probiotics work in the gut.
Benefits
- May support skin barrier health
- Potentially calming and soothing to irritated skin
- Could help balance skin microbiome
Science: Limited peer-reviewed data available for this ingredient. Most support comes from in vitro studies and manufacturer research rather than robust clinical trials in humans.
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Hexylene glycol is a lightweight humectant and preservative booster used in skincare products to help retain moisture and improve product stability. It also enhances the penetration of other active ingredients into the skin.
Benefits
- Helps skin retain moisture
- Improves product texture and spreadability
- Enhances effectiveness of preservative systems
Potential concerns
- May cause mild irritation or redness in sensitive individuals (occurs in roughly 3% of eczema-prone skin)
- Potential for delayed allergic contact reactions in susceptible people, though this is uncommon
- Less irritating than propylene glycol under occlusion, but still worth avoiding if you have known sensitivities to glycols
Science: A 1989 study found hexylene glycol caused visible skin reactions in 2.8% of eczema patients at high concentrations (30-50%), with potential for delayed allergic sensitization in rare cases. It was less irritating than propylene glycol. One case report mentions hexylene glycol as a potential allergen in medical formulations, though reactions are uncommon at typical cosmetic concentrations.
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Disodium EDTA is a chelating agent that binds to metals and minerals in skincare formulations, helping to preserve product stability and extend shelf life. It's used in small amounts (typically under 2%) to prevent unwanted chemical reactions that could degrade the formula.
Benefits
- Stabilizes cosmetic formulations by binding trace metals
- Extends product shelf life and maintains efficacy
- Allows other skincare ingredients to work more effectively
Potential concerns
- May increase skin penetration of other ingredients by chelating calcium in the skin barrier—only a concern if combined with potentially harmful substances
- Not absorbed through skin in normal use, but inhalation from sprays was identified as a theoretical concern in safety assessments
Science: The Cosmetic Ingredient Review Expert Panel confirmed safety in 2023 based on standard use concentrations. Clinical studies show no skin absorption; however, it can affect how other chemicals penetrate the skin, so formulators must account for this when combining with other actives.
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Gellan Gum is a natural polysaccharide (thickening agent) derived from bacteria that forms a gel-like texture in skincare products. It helps create smooth, spreadable formulas while supporting skin hydration and barrier function.
Benefits
- Creates a lightweight, gel-like texture that feels comfortable on skin
- Helps retain moisture and improve skin hydration
- Supports skin barrier function and may aid in skin repair
- Biodegradable and biocompatible with skin
Science: Recent research demonstrates that gellan gum-based hydrogels are effective carriers for skincare actives, particularly in treating UV-damaged skin and promoting skin regeneration. The ingredient is non-toxic, biodegradable, and shows strong biocompatibility, making it suitable for cosmetic formulations.
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Pentylene glycol is a lightweight humectant—a ingredient that draws water into the skin to improve hydration and texture. It's commonly used in serums, sunscreens, and moisturizers as a preservative booster and skin-conditioning agent.
Benefits
- Improves skin hydration by attracting moisture
- Lightweight feel, absorbs quickly without heaviness
- Helps preserve product stability and extends shelf life
Potential concerns
- Rare contact allergy reported in sensitive individuals
- Emerging evidence suggests it may be an uncommon cosmetic allergen—if you have sensitive or reactive skin, patch test first
Science: Safety studies show a high margin of safety at standard use levels (87–671 in adults), with minimal skin penetration due to the ingredient's volatility. However, recent dermatological reports flag pentylene glycol as an emerging contact allergen in some individuals, warranting attention for those with sensitive skin.
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Hydrolyzed hyaluronic acid is a smaller, broken-down form of hyaluronic acid—a naturally occurring substance that holds moisture in skin. The smaller molecular size allows it to penetrate the outer layers of skin more easily than regular hyaluronic acid, potentially delivering hydration deeper into the skin.
Benefits
- Enhanced skin hydration due to smaller molecular size and better penetration
- Helps plump and soften the appearance of fine lines
- Lightweight and suitable for layering with other skincare products
Science: Hydrolyzed hyaluronic acid is well-established in skincare for its hygroscopic properties (ability to attract and retain water). The cited research focuses on its use in advanced delivery systems like microneedles for pharmaceuticals and cosmetics, demonstrating its compatibility with sophisticated formulation technologies, though direct efficacy studies on topical application are limited in the provided literature.
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Sodium Hyaluronate Crosspolymer is a modified form of hyaluronic acid, a naturally occurring substance that holds moisture in skin. The crosslinked version is designed to stay on the skin's surface longer and provide sustained hydration, rather than absorbing deeply like standard hyaluronic acid.
Benefits
- Provides long-lasting hydration and moisture retention
- Creates a smoother skin feel and texture
- Helps plump fine lines temporarily through moisture
Science: Limited peer-reviewed data available for this specific crosslinked variant. Standard sodium hyaluronate has an extensive safety record as a humectant in skincare, and crosslinking is a common cosmetic chemistry technique to alter performance characteristics.
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Ethylhexylglycerin is a preservative and antimicrobial ingredient used to prevent bacterial growth and extend shelf life in skincare products. It's a multifunctional ingredient that helps keep formulations stable and free from contamination.
Benefits
- Prevents bacterial contamination in products
- Helps extend product shelf life
- Works synergistically with other preservatives for enhanced protection
Potential concerns
- May not be effective against all bacterial species (notably some Pseudomonas aeruginosa strains)
- Preservative-related sensitization possible in sensitive individuals, though uncommon
Science: Research shows ethylhexylglycerin has broad antimicrobial activity against many common cosmetic contaminants, though effectiveness varies by bacterial species. Studies demonstrate it can work synergistically with other preservative components to enhance biofilm inhibition.
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Chlorphenesin is a synthetic preservative used in skincare products to prevent bacterial and fungal growth, extending shelf life. It's a broad-spectrum antimicrobial agent that helps keep products safe from contamination during storage and use.
Benefits
- Prevents microbial contamination in skincare formulations
- Extends product shelf life
- Allows formulas to remain stable without refrigeration
Potential concerns
- May cause irritation to sensitive eyes and eye area when present in eye products
- Degrades under UV exposure, potentially creating more harmful breakdown products
- Limited long-term safety data in peer-reviewed literature
Science: Research shows chlorphenesin can be toxic to eye tissue cells at approved concentrations, particularly affecting meibomian glands. When exposed to sunlight, it breaks down into compounds like 4-chlorophenol that may be more ecotoxic than the original ingredient, though systemic absorption in skincare is typically minimal.
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Cellulose gum (also called carboxymethyl cellulose or CMC) is a natural thickener derived from plant cellulose. In skincare products, it creates a smooth texture, helps formulas spread evenly, and can form a light protective film on the skin's surface.
Benefits
- Improves product texture and spreadability
- Provides light film-forming properties for a polished feel
- Generally well-tolerated by most skin types
- Natural origin and biodegradable
Potential concerns
- May occasionally cause irritation in very sensitive skin
- Can feel sticky or heavy at high concentrations
Science: Cellulose gum is recognized as a safe, biocompatible polysaccharide widely used across food, cosmetic, and pharmaceutical industries. No significant safety concerns were identified in the available literature for cosmetic applications.
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2-Hexanediol is a humectant and preservative booster commonly used in skincare products to help retain moisture and extend shelf life. It works by drawing water into the skin while also enhancing the effectiveness of other preservatives, allowing brands to use lower amounts of traditional preservatives.
Benefits
- Hydrates and moisturizes skin by drawing in water
- Helps preserve products with lower preservative levels
- Works synergistically with other skincare ingredients like niacinamide
Potential concerns
- May cause cell viability concerns at concentrations above 1.0% in laboratory studies
- Limited real-world safety data in humans at typical skincare concentrations (usually 2-5%)
- Potential environmental concern if released into water systems
Science: While 2-hexanediol is widely used as a preservative substitute for parabens, recent cytotoxicity studies raise questions about safety at concentrations commonly found in skincare products (>2%). However, these findings are from laboratory cell studies and may not directly translate to human skin application. Further human safety studies are needed to confirm real-world risk.
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Potassium chloride is a mineral salt that helps regulate hydration and electrical balance in skin cells. In skincare products, it's typically used as a pH buffer or electrolyte to maintain product stability and skin barrier function.
Benefits
- Helps maintain skin's natural electrolyte balance
- Supports skin hydration at the cellular level
- Acts as a pH stabilizer in formulations
Potential concerns
- May cause irritation or stinging if used in high concentrations
- Can be irritating to sensitive or compromised skin barriers
- Intravenous studies show it can be a vesicant at high doses, though topical skincare concentrations are far lower
Science: The available research focuses primarily on intravenous potassium chloride extravasation complications and its role in swallowing physiology—not topical skincare applications. Limited peer-reviewed data exists specifically evaluating potassium chloride in cosmetic skincare formulations at typical use levels.
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Xanthan gum is a natural thickener derived from fermented bacteria that helps give skincare products a smooth, gel-like texture. It stabilizes formulas and prevents ingredients from separating, while also helping products spread evenly on skin.
Benefits
- Creates smooth, pleasant texture
- Stabilizes emulsions and prevents separation
- Improves product spreadability and application
Science: Xanthan gum is an FDA-approved, anionic polysaccharide with a long history of safe use across food, pharmaceutical, and cosmetic industries since 1969. Its performance as a thickener and stabilizer is well-established in scientific literature, with no notable skin irritation concerns reported.
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Carrageenan is a natural thickening and gelling ingredient extracted from red seaweed. In skincare products, it acts as a stabilizer and texture-builder, helping to create a smooth, gel-like consistency while maintaining product stability.
Benefits
- Creates smooth, gel-like texture in skincare formulations
- Helps stabilize and thicken products
- Natural origin from marine sources
- May have antioxidant properties
Potential concerns
- May cause sensitivity or irritation in individuals with seaweed allergies
- Some research suggests potential inflammatory effects with ingestion; topical use is considered safer but long-term effects are not extensively studied
- Can occasionally cause mild irritation in sensitive skin
Science: Carrageenan is a sulfated polysaccharide from red seaweed with documented antioxidant and potential immunomodulating properties. While widely used in cosmetics as a stabilizer and gelling agent, peer-reviewed research specifically evaluating its safety and efficacy in topical skincare applications remains limited; most evidence comes from food and pharmaceutical studies.
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Analysis not yet available for this ingredient.
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Ethyl hexanediol is a lightweight humectant and preservative booster derived from plants. It helps skin retain moisture and extends the shelf life of products by supporting their preservative systems.
Benefits
- Hydrates and moisturizes skin
- Helps products stay fresh longer
- Lightweight texture that absorbs easily
Potential concerns
- May cause irritation or sensitivity in very sensitive skin at high concentrations
- Can feel sticky at very high doses, though typical skincare levels are low
Science: Research shows ethyl hexanediol has antimicrobial properties and effective moisture-retention abilities. Early military studies confirmed its safety profile on human skin when used at typical cosmetic concentrations.
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Allantoin is a naturally derived compound that helps calm and soothe irritated skin. It works by promoting healing and reducing inflammation, making it a popular choice in products designed for sensitive or reactive skin.
Benefits
- Reduces skin inflammation and irritation
- Supports the skin barrier function
- Promotes gentle healing of compromised skin
- Well-tolerated by sensitive skin types
Science: Allantoin ranks among the top three most-used active ingredients in pharmacy-grade sensitive skin products, alongside niacinamide and oat extract. Scientific evidence supports its anti-inflammatory mechanism and barrier-supporting action, though clinical studies specifically testing it on sensitive skin volunteers remain limited.
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Dipotassium Glycyrrhizate is a potassium salt derived from licorice root that functions as a skin-conditioning agent. It's used in skincare products to help soothe and support skin clarity, and has been studied as part of formulations targeting uneven skin tone.
Benefits
- May help reduce the appearance of dark spots and hyperpigmentation
- Gentle skin-conditioning properties
- Well-tolerated in cosmetic formulations with minimal irritation risk
Science: A 2022 clinical study found that a serum containing dipotassium glycyrrhizate (along with other actives) showed statistically significant improvement in melasma with no signs of irritation over 12 weeks. The ingredient is approved by the Cosmetic Ingredient Review panel for use at concentrations up to 1%, with safety data showing it does not absorb significantly into tissues.
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Hydrolyzed Sodium Hyaluronate is a smaller, broken-down form of hyaluronic acid that penetrates skin more easily than its larger counterpart. It works as a humectant, drawing moisture from the environment into your skin to keep it hydrated and plump.
Benefits
- Deep hydration and moisture retention
- Improved skin plumpness and elasticity
- Lightweight texture that absorbs quickly
Science: Hyaluronic acid and its derivatives are well-established humectants with extensive safety data and a long history of use in cosmetics. Limited peer-reviewed data available specifically for the hydrolyzed sodium form, but it follows the same safety profile as other hyaluronic acid derivatives.
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Sodium acetylated hyaluronate is a modified form of hyaluronic acid, a naturally occurring compound that holds moisture in skin. This version is chemically altered to help protect your skin's structural proteins (collagen) from breaking down, potentially reducing the appearance of wrinkles over time.
Benefits
- May reduce the appearance of fine lines and wrinkles with regular use (2+ months)
- Provides immediate smoothing effect on skin texture within 6 hours of application
- Helps protect collagen from degradation caused by aging and environmental damage
- Supports skin hydration through moisture-binding properties
Science: A 2022 peer-reviewed study demonstrated that sodium acetylated hyaluronate inhibits matrix metalloproteinases (MMPs)—enzymes that break down collagen—in both young and aged skin exposed to UV and pollution. Clinical trials showed measurable reduction in wrinkle depth and number after 2 months of use, with visible smoothing effects visible within 6 hours.
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Hydroxyacetophenone is a naturally derived compound with antioxidant and antimicrobial properties. It's used in skincare products to help protect skin from environmental stress and maintain product freshness.
Benefits
- Antioxidant protection against free radicals
- Antimicrobial and antiseptic properties
- May help preserve product stability
Science: Research shows hydroxyacetophenone has demonstrated antioxidant, antibacterial, and antiseptic activities in cosmetic and pharmaceutical applications. However, peer-reviewed data specifically evaluating its safety profile and efficacy in topical skincare products for consumers is limited.
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Hyaluronic acid is a naturally occurring molecule found in your skin that acts like a sponge, holding water to keep skin hydrated and plump. In skincare products, it helps improve skin moisture, reduce the appearance of fine lines, and support overall skin texture and firmness.
Benefits
- Boosts skin hydration and moisture retention
- Helps reduce the appearance of fine lines and wrinkles
- Supports skin firmness and elasticity
- Well-tolerated and safe for most skin types
- May enhance effects of other anti-aging treatments
Science: Multiple clinical studies confirm hyaluronic acid is highly effective and well-tolerated for improving skin hydration and signs of aging. Research shows it works as an effective standalone treatment and also enhances results when combined with other anti-aging procedures, with benefits sustained over extended use periods.
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Potassium hyaluronate is the potassium salt form of hyaluronic acid, a naturally occurring substance found in skin and connective tissue. In skincare, it works as a humectant—drawing moisture from the air and deeper skin layers to the surface—helping skin feel plump and hydrated.
Benefits
- Increases skin hydration and moisture retention
- Helps skin appear smoother and more plump
- Lightweight and suitable for most skin types, including oily and sensitive skin
Science: A 2009 Cosmetic Ingredient Review safety assessment concluded that potassium hyaluronate is safe for use in cosmetics at concentrations up to 2%, with no evidence of toxicity, allergenicity, or reproductive harm across multiple animal and clinical studies. Widespread clinical use, particularly via injection, has shown a strong safety profile with minimal adverse reactions.
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This is a modified form of hyaluronic acid, a naturally occurring substance that holds water in the skin. The modification (adding a hydroxypropyltrimonium coating) makes it positively charged, allowing it to bind more effectively to skin and hair. It works as a humectant, drawing moisture into the skin for a hydrating effect.
Benefits
- Hydrates and plumps skin by attracting and holding water
- May provide longer-lasting hydration compared to unmodified hyaluronic acid
- Helps improve skin texture and smoothness
Science: Limited peer-reviewed data available for this specific ingredient. However, it is derived from hyaluronic acid, which has extensive safety and efficacy data in cosmetics, and the chemical modification is designed to improve performance rather than create safety concerns.
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Sodium polyacrylate is a synthetic polymer that absorbs and holds water, creating a gel-like texture. In skincare, it's used as a thickener and moisture-retention agent to improve product consistency and help keep skin hydrated.
Benefits
- Absorbs and retains moisture to support skin hydration
- Thickens product texture for better application and feel
- Creates a smooth, spreadable consistency in formulations
Science: Contact dermatitis research involving multiple UK hospital dermatology centres found that sensitisation to sodium polyacrylate is rare, indicating excellent safety for topical skincare use. The ingredient has also been studied for advanced biomedical applications including wearable sensors, demonstrating its biocompatibility.
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PEG-60 Hydrogenated Castor Oil is a gentle emulsifier and solubilizer derived from castor oil. It helps blend water and oil-based ingredients together in skincare formulas and can improve the spreadability and texture of products.
Benefits
- Helps stabilize and blend different ingredients in creams and lotions
- Improves product texture and how it spreads on skin
- Allows incorporation of oils into water-based formulas
Science: A 2015 toxicology review of PEG compounds found PEG-60 hydrogenated castor oil to be safe for cosmetic use at concentrations up to 100%. Recent research (2023) confirms its effectiveness and safety when used as an emulsifier in skincare formulations.
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Calcium lactate is a mineral compound that combines calcium with lactic acid. In skincare, it may help support skin structure and act as a pH buffer, though it's not primarily used as a standalone active ingredient.
Benefits
- Provides bioavailable calcium to support skin barrier function
- May help neutralize pH in formulations
- Supports remineralization of skin (based on dental research showing similar mechanisms)
Potential concerns
- Gastrointestinal distress can occur with high oral doses (topical use is likely minimal risk)
- Very limited peer-reviewed data on topical skincare efficacy specifically
Science: Research on calcium lactate primarily focuses on oral supplementation for exercise performance and dental erosion protection. Topical skincare applications lack substantial peer-reviewed evidence, though the ingredient's role in remineralization (shown in dental studies) suggests potential benefit for barrier support, and it is generally recognized as safe in cosmetics.
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