Ingredients
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Dimethicone is a silicone-based ingredient that forms a smooth, protective layer on your skin. It helps lock in moisture, creates a soft feel, and is commonly used in moisturizers and primers to improve product texture and skin hydration.
Benefits
- Improves skin hydration by creating a moisture-barrier layer
- Provides a smooth, silky feel to products and on skin
- Well-tolerated by sensitive and atopic (eczema-prone) skin
- Non-greasy alternative to heavier oils
Science: Clinical studies demonstrate dimethicone is safe and well-tolerated in children with atopic dermatitis from 12 months of age. Research shows moisturizers containing dimethicone effectively improve skin hydration in mild-to-moderate atopic dermatitis patients over 14 days.
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Glycerin is a naturally derived humectant—a ingredient that draws moisture from the air into your skin. It's one of the most widely used and well-studied moisturizing agents in skincare, helping skin feel softer and more hydrated.
Benefits
- Attracts and retains moisture in the skin
- Improves skin hydration and softness
- Helps strengthen skin barrier function
- Suitable for most skin types, including sensitive skin
Science: The Cosmetic Ingredient Review Expert Panel concluded glycerin is safe as used in cosmetics across all concentrations. Research shows glycerin effectively improves skin hydration and is well-tolerated with minimal irritation risk. It is also referenced in clinical guidelines for managing inflammatory skin conditions and maintaining skin integrity.
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Sodium hyaluronate is the salt form of hyaluronic acid, a naturally occurring substance found in your skin that acts like a moisture magnet. In skincare products, it absorbs water from the environment and binds it to your skin, helping to hydrate and plump the skin's surface.
Benefits
- Delivers intense hydration to the skin
- Helps reduce the appearance of fine lines by improving skin moisture
- Supports skin barrier function
- Suitable for all skin types, including sensitive and oily skin
Potential concerns
- In very dry climates with low humidity, it may draw moisture from deeper skin layers if not sealed with an occlusive product
- Rare allergic reactions are possible but extremely uncommon
Science: While the provided research focuses on intra-articular injections for joint health (showing good safety and efficacy), hyaluronic acid and its salt form are well-established in dermatology for topical hydration. The molecule's safety profile is well-documented across decades of use in medical and cosmetic applications, with severe adverse reactions being extremely rare.
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Tocopheryl acetate is a stable form of vitamin E, a fat-soluble antioxidant that helps protect skin from damage caused by free radicals and oxidative stress. It's commonly used in skincare products because it's more shelf-stable than other vitamin E forms and may help support the skin's natural barrier function.
Benefits
- Antioxidant protection against environmental damage
- Supports skin barrier health
- Stable ingredient with good shelf life in formulations
Science: Tocopheryl acetate is a well-established vitamin E ester that the body converts to free vitamin E for use. Research shows it functions as a lipid-soluble antioxidant; one recent study found it contributed to a moisturizer's beneficial effects on skin microbiota balance in atopic dermatitis models, though more direct clinical evidence on topical efficacy is limited.
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Disodium EDTA is a chelating agent that binds to metals and minerals in skincare formulations, helping to preserve product stability and extend shelf life. It's used in small amounts (typically under 2%) to prevent unwanted chemical reactions that could degrade the formula.
Benefits
- Stabilizes cosmetic formulations by binding trace metals
- Extends product shelf life and maintains efficacy
- Allows other skincare ingredients to work more effectively
Potential concerns
- May increase skin penetration of other ingredients by chelating calcium in the skin barrier—only a concern if combined with potentially harmful substances
- Not absorbed through skin in normal use, but inhalation from sprays was identified as a theoretical concern in safety assessments
Science: The Cosmetic Ingredient Review Expert Panel confirmed safety in 2023 based on standard use concentrations. Clinical studies show no skin absorption; however, it can affect how other chemicals penetrate the skin, so formulators must account for this when combining with other actives.
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Phenoxyethanol is a preservative that prevents bacteria, yeast, and mold from growing in skincare products, helping them stay fresh and safe to use. It has been used safely in cosmetics for decades and is effective at very low concentrations.
Benefits
- Prevents microbial contamination and product spoilage
- Broad-spectrum antimicrobial activity against bacteria and yeast
- Minimal impact on beneficial skin bacteria when used at approved levels
Potential concerns
- Rare allergic contact dermatitis in sensitive individuals
- May cause irritation if used in products at concentrations above 1%
Science: The European Scientific Committee on Consumer Safety considers phenoxyethanol safe for all consumers, including children, at concentrations up to 1%. Adverse effects observed in animal studies required exposure levels approximately 200 times higher than those in cosmetic products, and it is classified as one of the most well-tolerated preservatives in cosmetics.
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Yellow 5 (also called Tartrazine) is a synthetic yellow dye used to color skincare products. It has no active skincare benefits and serves purely to make products visually appealing.
Potential concerns
- May cause allergic reactions or sensitivity in people with tartrazine intolerance
- Can trigger reactions in individuals with aspirin sensitivity
- Potential for contact dermatitis in sensitive skin types
Science: Yellow 5 is approved by major regulatory bodies (FDA, EU) as a cosmetic colorant at specified concentrations. Limited peer-reviewed data exists on its dermatological effects, though it is generally considered safe at approved levels; however, some individuals report sensitivity reactions.
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Ethylhexylglycerin is a preservative and antimicrobial ingredient used to prevent bacterial growth and extend shelf life in skincare products. It's a multifunctional ingredient that helps keep formulations stable and free from contamination.
Benefits
- Prevents bacterial contamination in products
- Helps extend product shelf life
- Works synergistically with other preservatives for enhanced protection
Potential concerns
- May not be effective against all bacterial species (notably some Pseudomonas aeruginosa strains)
- Preservative-related sensitization possible in sensitive individuals, though uncommon
Science: Research shows ethylhexylglycerin has broad antimicrobial activity against many common cosmetic contaminants, though effectiveness varies by bacterial species. Studies demonstrate it can work synergistically with other preservative components to enhance biofilm inhibition.
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Chlorphenesin is a synthetic preservative used in skincare products to prevent bacterial and fungal growth, extending shelf life. It's a broad-spectrum antimicrobial agent that helps keep products safe from contamination during storage and use.
Benefits
- Prevents microbial contamination in skincare formulations
- Extends product shelf life
- Allows formulas to remain stable without refrigeration
Potential concerns
- May cause irritation to sensitive eyes and eye area when present in eye products
- Degrades under UV exposure, potentially creating more harmful breakdown products
- Limited long-term safety data in peer-reviewed literature
Science: Research shows chlorphenesin can be toxic to eye tissue cells at approved concentrations, particularly affecting meibomian glands. When exposed to sunlight, it breaks down into compounds like 4-chlorophenol that may be more ecotoxic than the original ingredient, though systemic absorption in skincare is typically minimal.
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C12-15 Alkyl Benzoate is a lightweight emollient (skin softener) derived from benzoic acid and plant-based alcohols. It's commonly used in sunscreens and moisturizers to create a smooth texture, help dissolve UV filters, and improve how the product feels on skin.
Benefits
- Provides a silky, non-greasy feel
- Helps dissolve and stabilize UV filters in sunscreens
- Lightweight emollient that conditions skin without heaviness
Science: Research shows C12-15 Alkyl Benzoate is effective as a sunscreen emollient, though studies indicate that more polar (water-loving) emollients like Dibutyl Adipate may provide slightly better UVA protection. The ingredient has a good safety profile in cosmetic formulations.
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Laureth-7 is a mild cleansing and emulsifying ingredient that helps oils and water mix together in skincare formulas. It's derived from lauryl alcohol and is commonly used to improve product texture and stability.
Benefits
- Helps formulations blend smoothly and feel consistent
- Aids in even distribution of active ingredients
- Allows water-based and oil-based ingredients to work together
Potential concerns
- Potential for contact dermatitis in sensitive individuals, particularly when combined with certain polymers
- May cause irritation in people with atopic or very reactive skin
Science: A 2019 case report documented contact dermatitis from a cream containing laureth-7 mixed with polyacrylamide and isoparaffin in patients with atopic skin, suggesting caution for sensitive individuals. Laureth-7 is used in various cosmetic formulations including sunless tanning and emollient products with generally acceptable safety profiles in most skin types.
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Kaolin is a naturally occurring clay mineral that works as an absorbent in skincare products. It helps remove excess oil and impurities from the skin's surface, making it a popular ingredient in masks and cleansers, particularly for oily or combination skin types.
Benefits
- Absorbs excess sebum and oil from skin
- Gentle physical exfoliant that removes dead skin cells
- Helps purify pores and reduce appearance of blemishes
- Soothing and calming for irritated skin
Potential concerns
- May be drying if used excessively or on already dry skin
- Can cause mild irritation in sensitive individuals
- May leave a slight residue or chalky feel if not rinsed thoroughly
Science: Kaolin is a well-established pharmaceutical and cosmetic ingredient with multiple documented applications in skincare, including oil absorption, skin protection, and anti-inflammatory properties. It has a long history of safe topical use and is recognized as biocompatible with minimal toxicity concerns.
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Palmitic acid is a naturally occurring fatty acid found in palm oil and animal fats that helps strengthen your skin's barrier and improve moisture retention. In skincare products, it acts as an emollient and emulsifier, making formulas smoother and helping other ingredients blend together.
Benefits
- Moisturizes and softens skin
- Strengthens skin barrier function
- Improves product texture and spreadability
Science: Palmitic acid is a well-established safe ingredient with a long history of use in cosmetics and food products. The provided research focuses on palmitic acid's metabolic role in systemic health contexts (cancer research), which is not relevant to topical skincare applications where absorption is minimal.
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Allantoin is a naturally derived compound that helps calm and soothe irritated skin. It works by promoting healing and reducing inflammation, making it a popular choice in products designed for sensitive or reactive skin.
Benefits
- Reduces skin inflammation and irritation
- Supports the skin barrier function
- Promotes gentle healing of compromised skin
- Well-tolerated by sensitive skin types
Science: Allantoin ranks among the top three most-used active ingredients in pharmacy-grade sensitive skin products, alongside niacinamide and oat extract. Scientific evidence supports its anti-inflammatory mechanism and barrier-supporting action, though clinical studies specifically testing it on sensitive skin volunteers remain limited.
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Jojoba seed oil is a natural oil extracted from jojoba plant seeds that closely mimics the skin's natural sebum. It's commonly used in skincare to moisturize, balance oil production, and improve skin texture without leaving a heavy residue.
Benefits
- Lightweight moisturization
- Helps balance oily and dry skin
- Rich in vitamin E and antioxidants
- Generally non-comedogenic (unlikely to clog pores)
Potential concerns
- Rare allergic reactions in sensitive individuals
- May not be suitable for very acne-prone skin in high concentrations
Science: Jojoba oil has a long history of safe use in cosmetics and is well-tolerated by most skin types. Limited peer-reviewed data available for this specific ingredient, but extensive industry experience and anecdotal evidence support its safety and efficacy as a natural moisturizer.
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Shea butter is a natural fat extracted from the nuts of the African shea tree. In skincare, it works as a rich moisturizer and skin conditioning agent that helps soften and protect the skin barrier.
Benefits
- Deep moisturization and hydration
- Skin conditioning and softening
- May help improve skin texture and elasticity
Potential concerns
- May cause sensitivity or irritation in some individuals; formulations should be tested to ensure non-sensitizing properties
- Quality varies by source—impurities in poorly processed shea butter could potentially cause irritation
Science: A 2024 safety assessment by the Cosmetic Ingredient Review Expert Panel concluded that shea-derived ingredients are safe at current use levels and concentrations when formulated to be non-sensitizing. Formulators should monitor for impurities and be aware of cumulative botanical constituents in multi-ingredient products.
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Fragrance (Parfum) is a concentrated blend of aromatic compounds—including essential oils, aroma chemicals, and natural extracts—added to skincare products to provide a pleasant scent. It serves no active skincare benefit and is purely for sensory appeal.
Benefits
- Enhances the sensory experience of using the product
- Can make the skincare routine feel more luxurious or enjoyable
Potential concerns
- May cause irritation or allergic contact dermatitis, especially in sensitive skin
- Can trigger headaches or respiratory sensitivity in some people
- Fragrance compounds may be comedogenic (pore-clogging) in acne-prone skin
- Some fragrance components degrade over time and can become irritating
Science: Fragrance is a common cause of contact dermatitis and allergic reactions in skincare. The specific composition of 'Fragrance' blends is proprietary and undisclosed, making it difficult to identify which compounds may trigger individual sensitivities. People with sensitive or reactive skin often benefit from fragrance-free alternatives.
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Yellow 6 is a synthetic colorant approved for use in cosmetics that gives products a yellow or golden hue. It serves purely an aesthetic purpose and has no active skincare benefits—it's added solely to make products visually appealing.
Potential concerns
- May cause allergic reactions or sensitivity in people with dye sensitivities
- Potential contact dermatitis in sensitive individuals
- Azo dye—some people prefer to avoid synthetic colorants on principle
Science: Yellow 6 (Tartrazine) is approved by regulatory bodies including the FDA and EU for cosmetic use at specified concentrations. Limited peer-reviewed dermatological data exists, but documented cases of colorant-related contact sensitization are rare in cosmetics. It is generally considered safe for topical use in the concentrations used in skincare products.
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Polyacrylamide is a synthetic polymer used in skincare products as a thickener and film-former that helps create smooth textures and provide a light protective layer on the skin. It's commonly found in gels, moisturizers, and other formulations where a stable, gel-like consistency is desired.
Benefits
- Creates smooth, spreadable product texture
- Helps products adhere to skin without feeling heavy
- Provides lightweight film-forming properties for a polished finish
Science: The Cosmetic Ingredient Review Expert Panel reaffirmed in 2023 that polyacrylamide is safe as a cosmetic ingredient at typical use concentrations and practices, based on a comprehensive review of available safety data. No significant dermatological concerns have been identified in peer-reviewed literature for topical cosmetic use.
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Cetyl alcohol is a fatty alcohol derived from natural sources like palm oil that works as an emollient and thickening agent in skincare products. It helps create a smooth texture, improve product consistency, and soften the skin by forming a light protective layer.
Benefits
- Softens and moisturizes skin
- Improves product texture and spreadability
- Helps stabilize emulsions (creams and lotions)
Potential concerns
- Very rare allergic reactions or contact sensitivity in susceptible individuals
- May cause mild irritation in products with high concentrations
Science: Cetyl alcohol has a long history of safe use in topical cosmetics with established safety data. Research indicates it forms nanostructured systems that interact well with skin and does not cause irritation or cellular toxicity in standard formulations.
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Zinc oxide is a mineral UV filter that sits on top of your skin to physically block both UVA and UVB rays from reaching your skin. It's one of the few sunscreen actives recognized as safe and effective by the FDA, and it doesn't get absorbed into your bloodstream.
Benefits
- Provides broad-spectrum UV protection (blocks both UVA and UVB rays)
- Mineral/physical blocker — doesn't absorb into skin, making it suitable for sensitive skin and safe during pregnancy
- Photostable — doesn't degrade in sunlight
- Generally well-tolerated with low risk of irritation or allergic reaction
Potential concerns
- Can leave a white cast on skin, especially at higher concentrations needed for adequate protection
- May feel heavy or thick in formulation
Science: Zinc oxide is a mineral UV filter with an established safety profile and is not systemically absorbed through skin. Current scientific evidence supports its efficacy and safety for routine sunscreen use, with no associated negative health effects documented. Unlike organic UV filters, it does not contribute to environmental concerns like coral bleaching.
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C13-14 Isoparaffin is a lightweight hydrocarbon oil derived from petroleum that acts as an emollient and slip agent in skincare products. It helps products spread smoothly across the skin and creates a soft, non-greasy feel while providing mild moisturizing properties.
Benefits
- Smooth, easy application
- Non-greasy skin feel
- Lightweight moisturizing
Potential concerns
- May clog pores in sensitive individuals
- Not ideal for acne-prone skin
Science: Limited peer-reviewed data available for this ingredient. It is approved for cosmetic use by regulatory authorities including the FDA and EU, and is considered safe at typical use levels in skincare formulations.
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Steareth-21 is an emulsifier—a helper ingredient that blends oil and water together in creams and lotions. It's made by combining stearic acid (a natural fatty acid) with ethylene oxide, creating a molecule that stabilizes skincare formulations and keeps them from separating.
Benefits
- Helps create stable, smooth emulsions in creams and lotions
- Improves product texture and spreadability
- Allows other active ingredients to be evenly distributed
Science: Research shows that steareth-21 used in oil-in-water emulsions significantly reduces skin penetration of certain sunscreen agents compared to other emulsifier systems, suggesting it creates a stronger barrier effect. This makes it a preferred choice in protective formulations where controlling ingredient absorption is desirable.
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Steareth-2 is a nonionic emulsifier derived from stearyl alcohol and ethylene oxide. It helps mix oil and water in skincare formulations to create stable, smooth creams and lotions.
Benefits
- Stabilizes oil-water emulsions
- Helps create smooth product texture
- Allows even distribution of active ingredients like sunscreens
Potential concerns
- May increase skin water loss (TEWL) in normal skin at typical use concentrations
- Can affect how much active ingredient penetrates the skin depending on formulation
Science: Research shows steareth-2 acts as an emulsifier but can alter skin barrier function—it increased transepidermal water loss in normal skin while unexpectedly decreasing it in damaged skin, suggesting it may interact with skin lipids. The ingredient also influences how effectively sunscreen agents penetrate or remain on the skin depending on the overall emulsion system used.
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